Obesity is not associated with adverse outcome following surgical resection of oesophageal adenocarcinoma

作者：Madani Koroush; Zhao Ronghua; Lim Hyun Ja; Casson Sharon M; Casson Alan G^*

来源：European Journal of Cardio-Thoracic Surgery, 2010, 38(5): 604-608.

DOI：10.1016/j.ejcts.2010.03.054

• Oesophagus
• Adenocarcinoma
• Obesity
• Outcome

Objective To study the impact of obesity on postoperative morbidity and outcome following surgical resection of primary oesophageal adenocarcinoma (EADC) Methods From a prospective database, we compared clinicopathological findings (age, gender, surgical approach, tumour differentiation and stage), postoperative mortality, morbidity, length of hospitalisation disease free survival (DFS) and overall survival (OS) between 56 obese (body mass index (BMI) >= 30 mg kg(-2)) and 86 non obese (BMI < 30 mg kg(-2)) patients with EADC Results In this consecutive series there were 118 male and 24 female patients with a median age of 63 years (range, 36-85 years) For all patients, the 5 year OS was 26 9% with a median survival of 20 months No significant differences (P > 0 05) were found between obese and non obese patients, with respect to age, gender surgical approach (transthoracic vs transhiatal), pT stage duration of hospital stay, postoperative mortality or morbidity However compared with non obese patients obese patients had a higher frequency of postoperative respiratory complications (odds ratio (OR) 3 05 95% confidence intervals (CIs), 1 29-7 17) DFS and OS at 5 years were increased for patients who were obese at the time of oesophageal resection (P = 0 008) Conclusions Obesity is not associated with increased postoperative complication rates or adverse outcome following oesophageal resection, and should therefore not be considered a relative contraindication to the surgical management of EADC The improved survival of obese patients who underwent oesophageal resection for EADC suggests that furt

• 出版日期2010-11