A biomimetic method to synthesise indolo[3,2-a]carbazoles

作者：Liang, Li-na; Fan, Tian-yun; Huang, Tao; Yan, Chen; Xu, Mei; Liu, Sheng^*

来源：Tetrahedron Letters, 2015, 56(2): 434-436.

DOI：10.1016/j.tetlet.2014.11.136

• Indolo[3,2-a]carbazoles
• Biomimetic synthesis
• Transamination
• Aromatic cyclisation

A simple and biomimetic synthetic strategy for indolo[3,2-a]carbazoles has been developed. Our approach involved the efficient conversion of 2-(3'-indolyl)tryptophan derivatives into the corresponding cc-keto esters and the subsequent aromatic cyclisation of these intermediates to construct the characteristic heteroaryl-condensed carbazole core.

• 出版日期2015-1-8
• 单位贵州省中国科学院天然产物化学重点实验室; 贵州大学