An ecofriendly approach to the synthesis of 2-imino- and 2-oxo-3-phenylsulfonyl-2H-chromenes

作者：Dias Tatiana A; Fernanda Proenca M

来源：Tetrahedron Letters, 2012, 53(39): 5235-5237.

DOI：10.1016/j.tetlet.2012.07.069

• Salicylaldehyde
• (Phenylsulfonyl)acetonitrile
• Chromene
• Aqueous base
• Synthesis

An efficient synthesis for 2-imino-3-phenylsulfonyl-2H-chromenes was developed from the Knoevenagel condensation of (phenylsulfonyl)acetonitrile and salicylaldehydes in aqueous sodium carbonate solution, at room temperature. Hydrolysis in aqueous HCl, at 80 degrees C, led to the formation of the corresponding 2-oxo-3-phenylsulfonyl-2H-chromenes, also isolated in excellent yields.

• 出版日期2012-9-26