A mild, catalytic and efficient Nazarov cyclization mediated by phosphomolybdic acid

作者:Murugan Kaliyappan; Srimurugan Sankareswaran; Chen Chinpiao*
来源:Chemical communications, 2010, 46(7): 1127-1129.
DOI:10.1039/b918137g

摘要

A mild, selective and efficient Nazarov cyclization of divinyl ketones catalyzed by phosphomolybdic acid (PMA) is described. The process demonstrates a broad substrate scope with functional group tolerance under short reaction times. PMA supported on silica gel is more efficient than the bulk catalyst and is recycled up to three times without significant activity loss.