科研之友
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摘要
Antimicrobial peptides have activity against a wide variety of biological membranes and are an important component of Innate immunity in vertebrate as well as Invertebrate systems The mechanisms of action of these peptides are Incompletely understood and a number of competing but not necessarily mutually exclusive models exist In this study we examined the virucidal activity of four peptides the human cathelicidin derived LL37 Xenopus alanine-substituted Magainin-2 amide uperin-3 1 and a cecropin-LL37 hybrid against vaccinia virus The peptides were shown to be differentially virucidal but all were shown to attack the viral envelope with LL37 being the most effective and uperin-3 1 the least Density gradient analysis of the treated virions indicated the virus outer membrane was efficiently removed by peptide action and suggests a mechanism of direct virus inactivation that is consistent with the carpet model for peptide-mediated membrane disruption Interestingly the least effective peptide uperin-3 1 was equally effective as the others at inducing susceptibility to neutralizing antibody This suggests that in addition
- 出版日期2010-11
