A novel biomimetic polymer as amphiphilic surfactant for soluble and biocompatible carbon nanotubes (CNTs)

作者：Xu Fang Ming; Xu Jian Ping^*; Ji Jian; Shen Jia Cong

来源：Colloids and Surfaces B: Biointerfaces , 2008, 67(1): 67-72.

DOI：10.1016/j.colsurfb.2008.07.016

• Carbon nanotubes
• Phosphorylcholine
• Cholesterol
• Biomimetic Biocompatibility

Novel amphiphilic diblock copolymer, cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine) (CPMPC), which has poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) as hydrophilic segment and cholesterol as hydrophobic segment, was specially designed as amphiphilic surfactant to achieve water-soluble and biocompatible carbon nanotubes (CNTs). The pristine CNTs were facilely dispersed via non-covalently binding the zwitterionic phosphorylcholine-based amphiphile onto the surfaces of the CNTs. It is interesting to find that CPMPC shows better CNTs solubilizing ability compared with the surfactant of pyrene-end-capped poly(2-methacryloyloxyethyl phosphorylcholine) (PPMPC). The biocompatibility of the CPMPC stabilized CNTs was evaluated using cholesterol-end-capped poly(2(dimethylamino) ethyl methacrylate) (CPDMAEMA), cholesterol-end-capped poly(acrylic acid) (CPAA) and cholesterol-end-capped poly(ethylene oxide) (CPEG) as surfactants for CNTs as controls. While CPDMAEMA stabilized CNTs and CPAA stabilized CNTs showed obvious cytotoxicity, cytotoxicity of this novel zwitterionic phosphorylcholine-based amphiphile stabilized CNTs was not observed as indicated by cell culture. The biocompatible CNTs represent an excellent nano-object for potential biomedical applications.

• 出版日期2008-11-15
• 单位浙江大学