Dementia is associated with Insulin Resistance in patients with Parkinson's Disease

作者：Bosco Domenico^*; Plastino Massimiliano; Cristiano Dario; Colica Carmela; Ermio Caterina; De Bartolo Matteo; Mungari Pasquale; Fonte Giulia; Consoli Domenico; Consoli Arturo; Fava Antonietta

来源：Journal of the Neurological Sciences, 2012, 315(1-2): 39-43.

DOI：10.1016/j.jns.2011.12.008

• Insulin Resistance
• 2 h-OGTT
• Parkinson Disease
• Dementia
• Diabetes mellitus

Background: Parkinson's disease is a neurodegenerative disorder involving the basal ganglia. Type-2 Diabetes Mellitus is an important risk factor for Alzheimer disease and vascular dementia. However, the association between Parkinson's disease and Diabetes Mellitus is controversial.
Objective: To investigate glucose metabolism abnormalities in 110 Parkinson's disease patients with and without dementia.
Subjects and Methods: We evaluated Insulin Resistance, glucose and insulin levels after a 2-h-oral-glucose-tolerance-test in 53 Parkinson's disease with dementia and 57 with Parkinson's disease without dementia, with normal fasting glucose.
Results: BMI, waist circumference, fasting glucose and insulin values, HbA1c, triglycerides, blood lipid profile, depression rating, educational levels, levodopa-dosage and antipsychotic use were similar in both groups. Disease duration and motor impairment were higher in patients with Parkinson's disease and dementia group. After 2-h-oral-glucose-tolerance-test, the prevalence of glucose metabolism abnormalities was significantly higher in group with Parkinson's disease and dementia group (p = 0.03). The insulin resistance was present in 62% patients with Parkinson's disease with dementia, of whom 30% had also impaired glucose tolerance, 5,6% newly diagnosed Diabetes Mellitus and 26% only Insulin Resistance. These percentages were significantly higher in group with Parkinson's disease and dementia, also after adjustment for disease duration and motor disability.

• 出版日期2012-4-15