Novel image derived parameters in PET/CT: Myths and reality

作者：Hatt M; Tixier F; Le Rest C Cheze; Visvikis D

来源：Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique, 2015, 39(3): 331-338.

DOI：10.1016/j.mednuc.2015.03.187

• Multimodality imaging
• 18FDG PET/CT
• Intratumor heterogeneity
• Multi-parametric models
• Textural features
• Metabolically active tumor volume
• Response prediction
• Prognosis

The role of multimodality imaging based on the use of positron emission tomography (PET) coupled to computerised tomography (CT) is continuously gaining ground in the field of oncology. The use of the technique in routine clinical practice is based on a visual interpretation or the determination of parameters such as the maximum standardised uptake value representing the highest activity voxel within the tumor. Other semi-quantitative parameters including the metabolic tumor volume and the total lesion glycolysis are increasingly used in the literature. More recently, alternative image derived parameters characterizing the tumor form and the heterogeneity in the intratumour activity distribution have been proposed. The objective of this article is to cover different aspects on these novel image derived indices, including: (i) the motivation behind their introduction and current use; (ii) obstacles in their utilization; (iii) methodological issues on their definition; (iv) their potential interest for future use in clinical practice.

• 出版日期2015-5