Analysis of molecular epidemiologic characteristics of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli colonizing feces in hospital patients and community dwellers in a Japanese city

作者：Nakamura Akihiro^*; Komatsu Masaru; Noguchi Nobuyoshi; Ohno Yuki; Hashimoto Eriko; Matsutani Hiroko; Abe Noriyuki; Fukuda Saori; Kohno Hisashi; Nakamura Fumihiko; Matsuo Shuji; Kawano Seiji

来源：Journal of Infection and Chemotherapy, 2016, 22(1-2): 102-107.

DOI：10.1016/j.jiac.2015.11.001

• ESBL
• Escherichia coli
• Molecular characterization
• Epidemiology

Infectious diseases caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are prevalent because of nosocomial infection. In addition, colonization of ESBL-producing E. coli in the intestinal tract of community dwellers due to the contamination of meat or environmental water is assumed to be one of the sources, but the causes have not been clarified. To analyze these factors, we investigated the difference in clonal groups using a combination of phylogenetic groups and multilocus sequence typing of ESBL-producing E. coli, which were obtained from the feces of an inpatient group in our hospital and a community-dwelling group living in a Japanese city. The carriage rate of ESBLproducing E. coil in the inpatient group was 12.5% (32/257), similar to that of 8.5% (42/496) in the community dwellers (P = 0.082). Of the ESBL clonal groups detected from the community dwellers, 52% (22/42) were clonal groups, including D-ST1485, D-ST70, D-ST2847, B2-ST550, B2-ST3510, A-ST93, AST580, A-ST716 and Bl-ST2787, that have not been detected from human pathogens, meat, companion animals and environmental water, whereas all clonal groups detected from the inpatients were those that had already been reported. The rate of fluoroquinolone-resistant ESBL clonal groups colonizing the intestinal tract of the inpatient group rose as the number of hospital days increased. These results indicated that different factors were related to colonization of ESBL-producing E. coli in the feces of the inpatient group and the community-dwelling group.

• 出版日期2016-2