Promotion Effects of Ultra-High Molecular Weight Poly-gamma-Glutamic Acid on Wound Healing

作者：Choi Jae Chul; Uyama Hiroshi; Lee Chul Hoon; Sung Moon Hee^*

来源：Journal of Microbiology and Biotechnology, 2015, 25(6): 941-945.

DOI：10.4014/jmb.1412.12083

• Ultra-high molecular weight poly-gamma-glutamic acid (UHMW gamma-PGA)
• wound healing

We examined the in vivo efficacy of ultra-high molecular weight poly-gamma-glutamic acid (UHMW gamma-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW gamma-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW gamma-PGA-treated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW gamma-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW gamma-PGA-treated groups. Increased levels of transforming growth factor-beta and p-catenin were also observed in skin samples collected from UHMW gamma-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW gamma-PGA promotes wound healing in vivo.

• 出版日期2015-6