A Facile Method of Using Sulfobetaine-Containing Copolymers for Biofouling Resistance

作者：Liu Qingsheng; Li Wenchen; Wang Hua; Liu Lingyun^*

来源：Journal of Applied Polymer Science, 2014, 131(18): 40789.

DOI：10.1002/APP.40789

• adsorption
• biomaterials
• biomedical applications
• coatings
• copolymers

Antifouling materials are desirable for many biomedical applications. In this work, the poly(sulfobetaine methacrylateco-butyl methacrylate) (PSB) copolymers were investigated for their antifouling properties. The copolymers were synthesized via a simple free-radical polymerization with feed ratio of the zwitterionic sulfobetaine methacrylate (SBMA) varying from 0 to 20 mol %. The polymer composition was verified by nuclear magnetic resonance. The enzyme-linked immunosorbent assay and surface plasmon resonance were used to evaluate protein adsorption on a series of PSB copolymers from the single protein solution of fibrinogen, undiluted human blood serum, and undiluted human blood plasma. Results show that the protein adsorption amount decreased with the increasing content of SBMA in the copolymers. The adsorption levels achieved by PSB containing 20 mol % SBMA (PSB20) were only 4, 17, and 15 ng/cm(2) from fibrinogen, serum, and plasma, respectively, which represented 99%, 90%, and 90% reduction compared with the adsorption amounts on poly(butyl methacrylate) with no SBMA. The PSB20 film also completely inhibited endothelial cell attachment. Fouling resistance of PSB polymers can be well correlated with their receding water contact angles, which represent the polymer surface compositions in aqueous environment. The excellent antifouling abilities of PSB copolymers, combined with the facial synthesis method, commercial availability of all monomers, and low cost, render them highly promising for wide practical applications. The polymers can be applied versatilely as both solvent-cast films and surface coatings.

• 出版日期2014-9-15