An Evolutionary View of the Mechanism for Immune and Genome Diversity

作者：Kato Lucia; Stanlie Andre; Begum Nasim A; Kobayashi Maki; Aida Masatoshi; Honjo Tasuku^*

来源：The Journal of Immunology, 2012, 188(8): 3559-3566.

DOI：10.4049/jimmunol.1102397

An ortholog of activation-induced cytidine deaminase (AID) was, evolutionarily, the first enzyme to generate acquired immune diversity by catalyzing gene conversion and probably somatic hypermutation (SHM). AID began to mediate class switch recombination (CSR) only after the evolution of frogs. Recent studies revealed that the mechanisms for generating immune and genetic diversity share several critical features. Meiotic recombination, V(D)J recombination, CSR, and SHM all require H3K4 trimethyl histone modification to specify the target DNA. Genetic instability related to dinucleotide or triplet repeats depends on DNA cleavage by topoisomerase 1, which also initiates DNA cleavage in both SHM and CSR. These similarities suggest that AID hijacked the basic mechanism for genome instability when AID evolved in jawless fish. Thus, the risk of introducing genome instability into nonimmunoglobulin loci is unavoidable but tolerable compared with the advantage conferred on the host of being protected against pathogens by the enormous Ig diversification. The Journal of Immunology, 2012, 188: 3559-3566.

• 出版日期2012-4-15