Acute kidney injury: a conspiracy of toll-like receptor 4 on endothelia, leukocytes, and tubules

作者：Lu Christopher Y^*; Winterberg Pamela D; Chen Jianlin; Hartono John R

来源：Pediatric Nephrology, 2012, 27(10): 1847-1854.

DOI：10.1007/s00467-011-2029-0

• Ischemic acute kidney injury
• Innate immunity
• Damage associated molecular patterns
• Toll-like receptor
• Transplant rejection

Ischemic acute kidney injury (AKI) contributes to considerable morbidity and mortality in hospitalized patients and can contribute to rejection during kidney transplantation. Maladaptive immune responses can exacerbate injury, and targeting these responses holds promise as therapy for AKI. In the last decade, a number of molecules and receptors were identified in the innate immune response to ischemia-reperfusion injury. This review primarily focuses on one pathway that leads to maladaptive inflammation: toll-like receptor 4 (TLR4) and one of its ligands, high mobility group box protein 1 (HMGB1). The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored.

• 出版日期2012-10