A Case of Hydroxychloroquine Induced Acute Generalized Exanthematous Pustulosis Confirmed by Accidental Oral Provocation

作者：Park Jae Jeong; Yun Sook Jung; Lee Jee Bum; Kim Seong Jin; Won Young Ho; Lee Seung Chul^*

来源：Annals of Dermatology, 2010, 22(1): 102-105.

DOI：10.5021/ad.2010.22.1.102

• Acute generalized exanthematous pustulosis
• Adverse drug reactions
• Hydroxychloroquine
• Provocation test

Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered. (Ann Dermatol 22(1) 102 similar to 105, 2010)

• 出版日期2010-2