ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi

作者：Paek I; Orci L; Ravazzola M; ErdjumentBromage H; Amherdt M; Tempst P; Sollner TH; Rothman JE

来源：The Journal of Cell Biology, 1997, 137(5): 1017-1028.

DOI：10.1083/jcb.137.5.1017

We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian V-SNARE implicated in Vesicular transport between the ER and the Golgi. ERS-24 is incorporated into 20S docking and fusion particles and disassembles from this complex in an ATP-dependent manner. ERS-24 has significant sequence homology to Sec22p, a V-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi. ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport Vesicles associated with these organelles.

• 出版日期1997-6-2