A transcervical amniotic fluid collector: a new medical device for the assessment of amniotic fluid in patients with ruptured membranes

作者：Lee Seung Mi; Romero Roberto^*; Park Joong Shin; Chaemsaithong Piya; Jun Jong Kwan; Yoon Bo Hyun

来源：Journal of Perinatal Medicine, 2015, 43(4): 381-389.

DOI：10.1515/jpm-2014-0276

• Amniocentesis
• alpha-fetoprotein
• beta-human chorionic gonadotrophin
• premature rupture of membranes
• prolactin
• PROM
• pPROM
• transcervical amniotic fluid collector
• Yoon's AF Collector (TM)

Aim: To describe a new device for the transcervical collection of amniotic fluid (AF) in patients with ruptured membranes, and to compare the concentration of proteins in fluid retrieved by transabdominal amniocentesis and the transcervical AF collector.
Study design: Paired AF samples were collected in patients with preterm prelabor rupture of membranes (PROM) (n = 11) by transabdominal amniocentesis and with the transcervical AF collector (Yoon's AF Collector T). Three proteins known to have high concentrations in AF [alpha-fetoprotein (AFP), beta-human chorionic gonadotrophin (beta-hCG), and prolactin] were measured.
Results: (1) There was a significant correlation between the concentrations of analytes in AF obtained by transabdominal amniocentesis and by the transcervical AF collector (r = 0.94, P < 0.001 for AFP; r = 0.96, P < 0.001 for beta-hCG; r = 0.72, P < 0.05 for prolactin); (2) Bland-Altman plots showed no evidence of heteroscedasticity between transabdominal or transcervical AF concentrations of these markers.
Conclusions: There was a strong correlation between the concentrations of proteins in AF collected by amniocentesis or with the transcervical device.

• 出版日期2015-7