A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice

作者：Kurahashi Toshihiro; Konno Tasuku; Otsuki Noriyuki; Kwon Myoungsu; Tsunoda Satoshi; Ito Junitsu; Fujii Junichi^*

来源：FEBS Letters, 2012, 586(24): 4289-4295.

DOI：10.1016/j.febslet.2012.09.047

• Chylomicron secretion
• Oxidative stress
• Superoxide dismutase
• Apolipoprotein B

We compared lipid metabolism in the intestines of Sod1-knockout mice with that found in wildtype mice to elucidate the impact of oxidative stress in vivo. A high-fat diet in wild-type mice induced postprandial hypertriglyceridemia, but this adaptive response was impaired in Sod1-knockout mice. While fewer triglycerides were secreted to the blood in the form of triglyceride-rich lipoprotein, more lipid droplets accumulated in the enterocytes of Sod1-knockout mice fed a high-fat diet. These data collectively suggest that high-fat diet induces oxidative stress, inhibits lipid secretion to the blood, and ultimately leads to dysfunctional lipid metabolism in enterocytes.

• 出版日期2012-12-14