An Alternative Synthesis of 3 ',4 '-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae

作者：Shih Tzenge Lien^*; Hsiao Chih Ang; Lin Zi Yu; Chen Yau Hung

来源：Molecules, 2012, 17(7): 8206-8216.

DOI：10.3390/molecules17078206

• antioxidant
• Baker-Venkataraman rearrangement
• diaminoflavones
• ROS-scavenging
• zebrafish larvae

We described herein a concise synthesis of 3',4'-diaminoflavone 10. This new, three-step synthetic approach is more efficient than the conventional seven-step synthetic method. The route is shortened significantly by introducing the amino moieties early and eliminating the need for nitro group reduction. The other two analogues, 5,7-dihydroxy-3',4'-diaminoflavone 11 and 5,7-dimethoxy-3',4'-diaminoflavone 12, were also synthesized similarly. The above three compounds, along with flavone, were evaluated for their antioxidant and UVB-protection abilities on zebrafish larvae. The data showed that compound 10 exhibited the best result, with -102.3% of ROS-scavenging rate.

• 出版日期2012-7