The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

作者：Huang Dong Ming^*; Hsiao Jong Kai; Chen Ying Chun; Chien Li Ying; Yao Ming; Chen Yin Kai; Ko Bor Sheng; Hsu Szu Chun; Tai Lin Ai; Cheng Hui Ying; Wang Shih Wei; Yang Chung Shi; Chen Yao Chang

来源：Biomaterials, 2009, 30(22): 3645-3651.

DOI：10.1016/j.biomaterials.2009.03.032

• Nanoparticle
• MRI
• Cell proliferation
• Mesenchymal stem cell
• Biocompatibility

Superparamagnetic iron oxide (SPIO) nanoparticles are very useful in cell imaging: meanwhile, however, biosafety concerns associated with their use, especially on therapeutic stem cells, have arisen. Most studies of biosafety issues focus on whether the nanoparticles have deleterious effects. Here, we report that Ferucarbotran, an ionic SPIO, is not toxic to human mesenchymal stem cells (hMSCs) under the conditions of these experiments but instead increases cell growth. Ferucarbotran-promoted cell growth is due to its ability to diminish intracellular H2O2 through intrinsic peroxidase-like activity. Also, Ferucarbotran can accelerate cell cycle progression, which may be mediated by the free iron (Fe) released from lysosomal degradation and involves the alteration of Fe on the expression of the protein regulators of the cell cycle.

• 出版日期2009-8