An unusual T-cell childhood acute lymphoblastic leukemia harboring a yet unreported near-tetraploid karyotype

作者：Garcia Daniela R N; Bhatt Samarth; Manvelyan Marina; de Souza Mariana T; Binato Renata; Aguiar Thais F; Abdelhay Eliana; Silva Maria Luiza M^*

来源：Molecular Cytogenetics, 2011, 4(1): 20.

DOI：10.1186/1755-8166-4-20

• T-ALL
• childhood
• near-tetraploidy

Background: Near-tetraploid (model #81-103) and near-triploid (model #67-81) karyotypes are found in around 1% of childhood acute lymphoblastic leukemia. Due to its rarity, these two cytogenetic subgroups are generally included in the hyperdiploid group (model # > 51). Therefore separate informations about these two subgroups are limited to a few reports. Some studies found that near-tetraploidy is relatively more frequent in higher median ages and it is associated to Frech-American-British Classification subtype L2. Although the mechanisms by which leukemic blast cells divide is still unclear, studies have suggested that hyperdiploidy, near-triploidy and neartetraploidy do not seem to share the same mechanism.
Findings: Herewith, we present a new childhood T-acute lymphoblastic leukemia case of near-tetraploid karyotype with loss of two p53-gene copies, characterized in detail by cytogenetic and molecular studies.
Conclusion: We suggest that p53 is a good target gene to be screened, once p53 is one of the main effectors of cell cycle checkpoints.

• 出版日期2011-9-21