Multi-OMICS: a critical technical perspective on integrative lipidomics approaches

作者：Kopczynski Dominik; Coman Cristina; Zahedi Rene P; Lorenz Kristina; Sickmann Albert; Ahrends Robert

来源：Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 2017, 1862(8): 808-811.

DOI：10.1016/j.bbalip.2017.02.003

During the past decades, high-throughput approaches for analyzing different molecular classes such as nucleic acids, proteins, metabolites, and lipids have grown rapidly. These approaches became powerful tools for getting a fundamental understanding of biological systems. Considering each approach and its results separately, relations and causal connections between these classes have no chance to be revealed, since only separate molecular snapshots are provided. Only a combined approach, not fully established yet, with the integration of the corresponding data, might yield a comprehensive and complete understanding of biological processes, such as crosstalk and interactions in signaling pathways. Taking two or more omics-methods into consideration for analysis is referred to as a multi-omics approach, which is gradually evolving. In this critical note, we briefly discuss the relevance, challenges, current state, and potential of data integration from multi-omics approaches, with a special focus on lipidomics analysis, listing the advantages and gaps in this field. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein.

• 出版日期2017-8