A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba

作者：Tang, Bin^*; Tu, Hua; Long, Han-An; Du, Jun; Guo, Jian-Min; Liu, Hong-Jin; Hu, Xin; Yang, Li; Du, Xi

来源：Journal of Asian Natural Products Research, 2017, 19(9): 941-945.

DOI：10.1080/10286020.2016.1275582

• Lauraceae
• Litsea cubeba
• benzylisoquinoline
• X-ray diffraction
• cytotoxicity

A new benzylisoquinoline alkaloid (center dot)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0M, respectively, comparable to 3.1 and 17.5M of the cisplatin (positive control).

• 出版日期2017
• 单位宜宾学院