Neuregulin-ErbB4 signaling in the developing lung alveolus: a brief review

作者：Fiaturi Najla; Castellot John J Jr^*; Nielsen Heber C

来源：Journal of Cell Communication and Signaling, 2014, 8(2): 105-111.

DOI：10.1007/s12079-014-0233-y

• ErbB4
• Neuregulin
• TACE
• Gamma Secretase
• Pulmonary Surfactant
• Presenilin
• 4ICD

Lung immaturity is the major cause of morbidity and mortality in premature infants, especially those born <28 weeks gestation. Proper lung development from 23-28 weeks requires coordinated cell proliferation and differentiation. Infants born at this age are at high risk for respiratory distress syndrome (RDS), a lung disease characterized by insufficient surfactant production due to immaturity of the alveoli and its constituent cells in the lung. The ErbB4 receptor and its stimulation by neuregulin (NRG) plays a critical role in surfactant synthesis by alveolar type II epithelial cells. In this review, we first provide an introduction to normal human alveolar development, followed by a discussion of the neuregulin and ErbB4-mediated mechanisms regulating alveolar development and surfactant production.

• 出版日期2014-6