Apparent motion photometry: evaluation and reliability of a novel method for the measurement of macular pigment

作者：Bartlett Hannah^*; Eperjesi Frank

来源：British Journal of Ophthalmology, 2011, 95(5): 662-665.

DOI：10.1136/bjo.2009.178137

Background/aims Macular pigment is thought to protect the macula against exposure to light and oxidative stress, both of which may play a role in the development of age-related macular degeneration. The aim was to clinically evaluate a novel cathode-ray-tube-based method for measurement of macular pigment optical density (MPOD) known as apparent motion photometry (AMP).
Methods The authors took repeat readings of MPOD centrally (0 degrees) and at 3 degrees eccentricity for 76 healthy subjects (mean (+/- SD) 26.5 +/- 13.2 years, range 18-74 years).
Results The overall mean MPOD for the cohort was 0.50 +/- 0.24 at 0 degrees, and 0.28 +/- 0.20 at 3 degrees eccentricity; these values were significantly different (t = -8.905, p<0.001). The coefficients of repeatability were 0.60 and 0.48 for the 0 and 3 degrees measurements respectively.
Conclusions The data suggest that when the same operator is taking repeated 0 degrees AMP MPOD readings over time, only changes of more than 0.60 units can be classed as clinically significant. In other words, AMP is not suitable for monitoring changes in MPOD over time, as increases of this magnitude would not be expected, even in response to dietary modification or nutritional supplementation.

• 出版日期2011-5