Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

作者：Hisatsune Chihiro^*; Yasumatsu Keiko; Takahashi Iwanaga Hiromi; Ogawa Naoko; Kuroda Yukiko; Yoshida Ryusuke; Ninomiya Yuzo; Mikoshiba Katsuhiko

来源：JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282(51): 37225-37231.

DOI：10.1074/jbc.M705641200

Inositol 1,4,5-trisphosphate receptor (IP3R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiological phenomena. Type 3 IP3R is expressed in taste cells, but the physiological relevance of this receptor in taste perception in vivo is still unknown. Here, we show that mice lacking IP(3)R3 show abnormal behavioral and electrophysiological responses to sweet, umami, and bitter substances that trigger G-protein-coupled receptor activation. In contrast, responses to salty and acid tastes are largely normal in the mutant mice. We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta 2 to TRPM5 activation.

• 出版日期2007-12-21
• 单位河北医科大学