摘要

ObjectiveTo evaluate the anti-nociceptive and sedative effects of slow intravenous (IV) injection of tramadol, romifidine, or a combination of both drugs in ponies. Study designWithin-subject blinded. AnimalsTwenty ponies (seven male, 13 female, weighing meanSD 268.0128kg). MethodsOn separate occasions, each pony received one of the following three treatments IV; romifidine 50gkg(-) (R) tramadol 3mgkg(-1) given over 15minutes (T) or tramadol 3mgkg(-1)followed by romifidine 50gkg(-1) (RT). Physiologic parameters and caecal borborygmi (CB) were measured and sedation and response to electrical stimulation of the coronary band assessed before and up to 120minutes following drugs administration. Results were analyzed using the Friedman's test and 2 way anova as relevant. ResultsWhen compared to baseline, heart (HR, beats minute(-1)) and respiratory rates (f(R), breaths minute(-1)) increased with treatment T (highest mean +/- SD, HR 43 +/- 1; f(R) 33 +/- 2) and decreased with R (lowest HR 29 +/- 1 and f(R) 10 +/- 4) and RT (lowest HR 32 +/- 1 and f(R) 9 +/- 3). There were no changes in other measured physiological variables. The height of head from the ground was lower following treatments R and TR than T. There was slight ataxia with all three treatments. No excitatory behavioural effects were observed. The response to electrical stimulation was reduced for a prolonged period relative to baseline following all three treatments, the effect being significantly greatest with treatment RT. ConclusionTramadol combined with romifidine at the stated doses proved an effective sedative and anti-nociceptive combination in ponies, with no unacceptable behavioural or physiologic side effects. Clinical relevanceSlow controlled administration of tramadol should reduce the occurrence of adverse behavioural side effects.

  • 出版日期2015-3