Acquired resistance to voriconazole and itraconazole in a patient with pulmonary aspergilloma

作者：Bellete Bahrie; Raberin Helene^*; Morel Jerome; Flori Pierre; Hafid Jamal; Manhsung Roger Tran

来源：Medical Mycology, 2010, 48(1): 197-200.

DOI：10.3109/13693780902717018

• voriconazole
• itraconazole
• resistance
• Aspergillus fumigatus

We describe the development of resistance in an Aspergillus fumigatus strain, originally sensitive to itraconazole and voriconazole, recovered from a case of pulmonary aspergilloma treated with voriconazole. A G448S mutation on the cyp51A gene was detected by sequencing. Frequent culture and in vitro antifungal susceptibility testing is suggested for early detection of the development of multi-azole resistance in patients on long-term therapy for A. fumigatus infections.

• 出版日期2010-2