Advances in genetically modified Aedes aegypti to control transmission of dengue viruses

作者：Olson Ken E^*; Franz Alexander W E

来源：Future Virology, 2015, 10(5): 609-624.

DOI：10.2217/FVL.15.38

• Aedes aegypti
• dengue viruses
• gene drive
• genetically modified mosquitoes
• population reduction
• population replacement
• promoter
• RIDL
• transgene introgression
• Wolbachia

Dengue viruses (DENV) are mosquito-borne viruses that infect millions of humans each year. DENVs are endemic in tropical regions of the world and maintained in a transmission cycle between mosquito vectors (Aedes aegypti) and humans. DEN disease control relies on vector control approaches that have had limited success and are difficult to sustain. Genetically modified mosquitoes (GMM) may be an alternative control strategy to limit DENV transmission. GMM-based control strategies include: conditional expression of a dominant lethal gene (RIDL) to reduce vector populations; and introgression of antipathogen (AP) genes into wild-type vectors for population replacement. In this review, we describe novel GMM-based strategies to limit DENV transmission and discuss potential hurdles to their successful implementation in the field.

• 出版日期2015