Assessing Genome-Wide Statistical Significance for Large p Small n Problems

作者:Diao Guoqing*; Vidyashankar Anand N
来源:GENETICS, 2013, 194(3): 781-+.
DOI:10.1534/genetics.113.150896

摘要

Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.

  • 出版日期2013-7