Dithiol-based modification of poly(dopamine): enabling protein resistance via short-chain ethylene oxide oligomers

作者：Vaish Amit^*; Vanderah David J; Richter Lee J; Dimitriou Michael; Steffens Kristen L; Walker Marlon L

来源：Chemical Communications, 2015, 51(30): 6591-6594.

DOI：10.1039/c5cc00299k

We present a facile strategy to modify poly(dopamine) (PDA)-coated substrates. Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer. Surprisingly, dithiol-terminated OEG molecules demonstrated significantly greater coverage on PDA surfaces than analogous monothiol molecules. Successful RPA is only achieved with dithiol-terminated OEGs.

• 出版日期2015