A cortical-spinal prosthesis for targeted limb movement in paralysed primate avatars

作者：Shanechi Maryam M; Hu Rollin C; Williams Ziv M^*

来源：Nature Communications, 2014, 5(1): 3237.

DOI：10.1038/ncomms4237

Motor paralysis is among the most disabling aspects of injury to the central nervous system. Here we develop and test a target-based cortical-spinal neural prosthesis that employs neural activity recorded from premotor neurons to control limb movements in functionally paralysed primate avatars. Given the complexity by which muscle contractions are naturally controlled, we approach the problem of eliciting goal-directed limb movement in paralysed animals by focusing on the intended targets of movement rather than their intermediate trajectories. We then match this information in real-time with spinal cord and muscle stimulation parameters that produce free planar limb movements to those intended target locations. We demonstrate that both the decoded activities of premotor populations and their adaptive responses can be used, after brief training, to effectively direct an avatar's limb to distinct targets variably displayed on a screen. These findings advance the future possibility of reconstituting targeted limb movement in paralysed subjects.

• 出版日期2014-2