An efficient and reusable PdCl2/TBAF system for the Heck reaction under ligand- and solvent-free conditions

作者:Tao, Li Ming*; Li, Qiang Guo; Liu, Wen Qi; Zhou, Yun; Zhou, Ju Feng
来源:Journal of Chemical Research, 2010, (4): 211-213.
DOI:10.3184/030823410X12706650130972

摘要

PdCl2 combined with TBAF (n-Bu4NF) were found to be efficient conditions for the Heck reactions. In the presence of PdCl2 and TBAF, a variety of aryl halides were coupled with alkenes smoothly in moderate to good yields. Moreover, the PdCl2/TBAF system could be recovered and reused several times in the reaction. Note that these reactions are conducted under solvent-free, ligand-free and reusable conditions.