Limitation of HIF-1 alpha with pentoxifillyne on renal tubular ischemia result of hiperoxaluria and ESWL.

作者：Erturhan Sakip; Bayrak Omer^*; Seckiner Ilker; Celik Mehmet; Karakok Metin

来源：Archivos Espanoles de Urologia, 2014, 67(2): 191-197.

• Hyperoxaluria, Hypoxia-Inducible Factor 1 Subunit alpha, Extracorporeal Shock Wave Lithotripsy
• Pentoxifylline

OBJECTIVES: To evaluate hypoxia-inducible factor 1 subunit alpha (HIF-1 alpha) expression during the performance of extracorporeal shock wave lithotripsy (ESWL) and to investigate the effects of pentoxyphylline on HIF-1 alpha expression.
METHODS: One hundred New Zealand Albino rabbit were used in the study divided in 5 groups. There were 20 rabbits in each group. The groups were divided in two parts: early (7 days) and late period (14 days) according to follow up duration. Immunohistochemical analyses were performed using nuclear staining to show HIF-1 alpha expression in rabbit renal tissue sample.
RESULTS: HIF-1 alpha expression was higher in rabbits undergoing ESWL (group 4). In the hyperoxaluria group taking pentoxyphylline before ESWL (group 5), HIF-1 alpha expression was lower in both early and late period subgroups (p<0.05)
CONCLUSION: In this study we evaluated HIF-1 alpha expression and showed that ESWL may cause renal cell injury. Our results suggest that pentoxyphylline, as a circulatory regulator agent, may prevent renal cell injury induced by ESWL.

• 出版日期2014-3