Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure

作者：Fan Li hong; Tian Hong yan; Ma Ai qun^*; Hu Zhi; Huo Jian hua; Cao Yong xiao

来源：Acta Pharmacologica Sinica, 2008, 29(10): 1167-1174.

DOI：10.1111/j.1745-7254.2008.00810.x

• ATP-sensitive potassium channel
• obesity-hypertension
• electrophysiology
• aorta
• mesenteric artery

Aim: To determine whether ATP-sensitive potassium channels are altered in VSMC from arotas and mesenteric arteries of obese rat, and their association with obesity-triggered increase in blood pressure. Methods: Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats. Control rats were fed with standard laboratory rat chow. Blood pressure and body weight of these rats were measured every 4 weeks. At the end of 24 weeks, K-ATP channel-mediated relaxation responses in the aortas and mesenteric arteries, K-ATP channel current, and gene expression were examined, respectively. Results: Blood pressure and body weight were increased in rats fed with high-fat diet. K-ATP channel-mediated relaxation responses, currents, and K-ATP expression in VSMC of both aortas and mesenteric arteries were inhibited in these rats. Conclusion: Altered ATP-sensitive potassium channels in obese rats may underscore obesity-triggered increase in blood pressure.

• 出版日期2008-10
• 单位西安交通大学