A Meta-Analysis of the Short- And Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Open Colectomy for Colon Cancer

作者：Ohtani Hiroshi^*; Tamamori Yutaka; Arimoto Yuichi; Nishiguchi Yukio; Maeda Kiyoshi; Hirakawa Kosei

来源：Journal of Cancer, 2012, 3: 49-57.

DOI：10.7150/jca.3621

• meta-analysis
• laparoscopy-assisted colectomy
• colon cancer

Purpose: We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. %26lt;br%26gt;Methods: We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between January 1990 and October 2011 by using the search terms %26quot;laparoscopy,%26quot; %26quot;laparoscopy-assisted,%26quot; %26quot;surgery,%26quot; %26quot;colectomy,%26quot; %26quot;colon cancer,%26quot; and %26quot;randomized clinical trials (RCTs)%26quot;. We analyzed the outcomes of each type of surgery over short-and long-term periods. %26lt;br%26gt;Results: We selected 12 papers reporting RCTs that compared LAC with OC for colon cancer. Our meta-analysis included 4614 patients with colon cancer; of these, 2444 had undergone LAC and 2170 had undergone OC. In the short-term period, we found that the rates of overall postoperative complications and ileus in LAC were lower than in OC groups. LAC was associated with a reduction in intraoperative blood loss, a shorter duration of time to resumption and hospital stay, and lower rates of overall complication and ileus over the short-term, but with similar long-term oncologic outcomes such as overall and cancer-related mortality, overall recurrence, local recurrence, distant metastasis, and wound-site recurrence, compared to OC. %26lt;br%26gt;Conclusions: It is suggested that LAC may be preferred to OC for colon cancer.

• 出版日期2012