Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation

作者：Shi, Jian-Quan; Zhang, Chu-Chu; Sun, Xiu-Lan; Cheng, Xin-Xin; Wang, Jiang-Bo; Zhang, Ying-Dong; Xu, Jun^*; Zou, Hai-Qiang

来源：CNS Neuroscience & Therapeutics, 2013, 19(4): 262-268.

DOI：10.1111/cns.12066

• Amyloid beta
• Artemisinin
• BACE1
• NALP3 inflammasome
• NF-B

Background The activation of nuclear factor-kappa B (NF-B) and NLRP3 inflammasome is involved in neuroinflammation, which is closely linked to Alzheimer's disease (AD). In vivo and in vitro studies have suggested that artemisinin shows antiinflammatory effects in inflammation-related diseases. However, the impacts of artemisinin on AD have not been investigated. Aims In this study, 5-month-old APPswe/PS1dE9 transgenic mice were treated daily with 40mg/kg artemisinin for 30days by intraperitoneal injection to evaluate the effects of artemisinin on AD. Results We found that artemisinin treatment (1) decreased neuritic plaque burden; (2) did not alter A transport across the bloodbrain barrier; (3) regulated APP processing via inhibiting -secretase activity; (4) inhibited NF-B activity and NALP3 inflammasome activation in APPswe/PS1dE9 double transgenic mice. Conclusions The in vivo study clearly demonstrates that artemisinin has protective effects on AD pathology due to its effects on suppressing NF-B activity and NALP3 inflammasome activation. Our study suggests that targeting NF-B activity and NALP3 inflammasome activation offers a valuable intervention for AD.

• 出版日期2013-4
• 单位南京医科大学