Neuroprotective effect of Shenqi Fuzheng injection pretreatment in aged rats with cerebral ischemia/reperfusion injury

作者：Cai, Ying-min; Zhang, Yong^*; Zhang, Peng-bo; Zhen, Lu-ming; Sun, Xiao-ju; Wang, Zhi-ling; Xu, Ren-yan; Xue, Rong-liang

来源：Neural Regeneration Research, 2016, 11(1): 94-100.

DOI：10.4103/1673-5374.175052

• nerve regeneration
• cerebral ischemia/reperfusion
• Shenqi Fuzheng injection
• aged rats
• neurological function
• Ca2+
• oxygen free radicals
• NSFC grant
• neural regeneration

Shenqi Fuzheng injection is extracted from the Chinese herbs Radix Astragali and Radix Codonopsis. The aim of the present study was to investigate the neuroprotective effects of Shenqi Fuzheng injection in cerebral ischemia and reperfusion. Aged rats (20-22 months) were divided into three groups: sham, model, and treatment. Shenqi Fuzheng injection or saline (40 mL/kg) was injected into the tail vein daily for 1 week, after which a cerebral ischemia/reperfusion injury model was established. Compared with model rats that received saline, rats in the treatment group had smaller infarct volumes, lower brain water and malondialdehyde content, lower brain Ca2+ levels, lower activities of serum lactate dehydrogenase and creatine kinase, and higher superoxide dismutase activity. In addition, the treatment group showed less damage to the brain tissue ultrastructure and better neurological function. Our findings indicate that Shenqi Fuzheng injection exerts neuroprotective effects in aged rats with cerebral ischemia/reperfusion injury, and that the underlying mechanism relies on oxygen free radical scavenging and inhibition of brain Ca2+ accumulation.

• 出版日期2016-1
• 单位西安交通大学