Noncoding after All: Biases in Proteomics Data Do Not Explain Observed Absence of lncRNA Translation Products

作者:Verheggen Kenneth; Volders Pieter Jan; Mestdagh Pieter; Menschaert Gerben; Van Damme Petra; Gevaert Kris; Martens Lennart*; Vandesompele Jo
来源:Journal of Proteome Research, 2017, 16(7): 2508-2515.
DOI:10.1021/acs.jproteome.7b00085

摘要

Over the past decade, long noncoding RNAs (lncRNAs) have emerged as novel functional entities of the eukaryotic genome. However, the scientific community remains divided over the amount of true noncoding transcripts among the large number of unannotated transcripts identified by recent large scale and deep RNA-sequencing efforts. Here, we systematically exclude possible technical reasons underlying the absence of lncRNA-encoded proteins in mass spectrometry data sets, strongly suggesting that the large majority of lncRNAs is indeed not translated.

  • 出版日期2017-7