Pulmonary manifestations of peripheral T-cell lymphoma: case report and review of the literature

作者：Vahid Bobbak^*; Machare Delgado Enrique; Marik Paul E

来源：Clinical Respiratory Journal, 2007, 1(2): 114-117.

DOI：10.1111/j.1752-699X.2007.00025.x

• non-Hodgkin's lymphoma
• peripheral T -cell lymphoma
• pulmonary nodule

Introduction: Peripheral T-cell lymphomas (PTCL) represent approximately 10% of non-Hodgkin's lymphomas. Pulmonary involvement is an uncommon manifestation of this heterogeneous group of malignancies.
Methods: Report of a case.
Results: This case report describes a 75-year-old man with fever, weight loss, anemia, enlargement of spleen and liver, atypical lymphocytes and pulmonary nodules. Lung biopsy showed lymphocytic infiltration of the lung parenchyma. T-cell receptor gamma gene rearrangement by polymerase chain reaction confirmed the diagnosis of peripheral T-cell lymphoma. Unfortunately, the patient died because of refractory and aggressive disease.
Conclusion: Pulmonary and pleural involvement are seen in patients with PTCL and usually carry a poor prognosis. The subject of pulmonary involvement in peripheral T-cell lymphoma is discussed.

• 出版日期2007-12