Natural compounds with Wnt signal modulating activity

作者:Fuentes Rolly G; Arai Midori A; Ishibashi Masami
来源:Natural Product Reports, 2015, 32(12): 1622-1628.
DOI:10.1039/c5np00074b

摘要

The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been developed to rapidly identify compounds, including natural compounds, that target the Wnt signal. Some studies on natural modulators of the Wnt signal have also suggested their possible target. This review highlights some important natural compounds reported to regulate Wnt activity and describes their possible mechanism of action.

  • 出版日期2015