A Facile, One-Step Nanocarbon Functionalization for Biomedical Applications

作者：Swierczewska Magdalena; Choi Ki Young; Mertz Edward L; Huang Xinglu; Zhang Fan; Zhu Lei; Yoon Hong Yeol; Park Jae Hyung; Bhirde Ashwinkumar; Lee Seulki^*; Chen Xiaoyuan

来源：Nano Letters, 2012, 12(7): 3613-3620.

DOI：10.1021/nl301309g

• Carbon nanomaterials
• one-step functionalization
• hyaluronic acid
• nanotubes
• molecular imaging

Despite their immense potential in biomedicine, carbon nanomaterials suffer from inefficient dispersion and biological activity in vivo. Here we utilize a single, yet multifunctional, hyaluronic acid-based biosurfactant to simultaneously disperse nanocarbons and target single-walled carbon nanotubes (SWCNTs) to CD44 receptor positive tumor cells with prompt uptake. Cellular uptake was monitored by intracellular enzyme-activated fluorescence, and localization of SWCNTs within cells was further confirmed by Raman mapping. In vivo photoacoustic, fluorescence, and positron emission tomography imaging of coated SWCNTs display high tumor targeting capability while providing long-term, fluorescence molecular imaging of targeted enzyme events. By utilizing a single biomaterial surfactant for SWCNT dispersion without additional bioconjugation, we designed a facile technique that brings nanocarbons closer to their biomedical potential.

• 出版日期2012-7
• 单位厦门大学