Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival

作者：Arnold M L; Bach C^*; Heinemann F M; Horn P A; Ziemann M; Lachmann N; Muehlbacher A; Dick A; Ender A; Thammanichanond D; Schaub S; Honger G; Fischer G F; Mytilineos J; Hallensleben M; Hitzler W E; Seidl C; Spriewald B M

来源：International Journal of Immunogenetics, 2018, 45(3): 95-101.

DOI：10.1111/iji.12363

• antibodies
• graft rejection
• graft survival
• histocompatibility testing
• immunoglobulin isotypes
• transplantation

We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold etal., ). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.

• 出版日期2018-6