A facile one-pot synthesis of 2-thioxo-dihydropyrimidines and polyfunctionalized pyran derivatives as mimics of novel calcium channel modulators

作者：Yadlapalli Rama Krishna; Chourasia O P; Perali Ramu Sridhar^*

来源：Tetrahedron Letters, 2012, 53(49): 6725-6728.

DOI：10.1016/j.tetlet.2012.10.020

• Piperidinylamide
• Dihydropyrimidines
• Polyfunctionalized pyrans
• Multi-component reaction
• Calcium channel modulator

An efficient protocol for the synthesis of pharmacologically significant dihydropyrimidines and polyfunctionalized pyrans is described by performing a one-pot multicomponent reaction (MCR). A chemistry-driven drug discovery approach is implemented by keeping an essential skeleton of calcium channel modulators in all the synthesized derivatives.

• 出版日期2012-12-5