Automatic 3D registration of dynamic stress and rest Rb-82 and flurpiridaz F 18 myocardial perfusion PET data for patient motion detection and correction

作者：Woo Jonghye; Tamarappoo Balaji; Dey Damini; Nakazato Ryo; Le Meunier Ludovic; Ramesh Amit; Lazewatsky Joel; Germano Guido; Berman Daniel S; Slomka Piotr J^*

来源：Medical Physics, 2011, 38(11): 6313-6326.

DOI：10.1118/1.3656951

• motion correction and detection
• image registration
• flurpiridaz F 18
• cardiac PET myocardial perfusion imaging

Purpose: The authors aimed to develop an image-based registration scheme to detect and correct patient motion in stress and rest cardiac positron emission tomography (PET)/CT images. The patient motion correction was of primary interest and the effects of patient motion with the use of flurpiridaz F 18 and Rb-82 were demonstrated.
Methods: The authors evaluated stress/rest PET myocardial perfusion imaging datasets in 30 patients (60 datasets in total, 21 male and 9 female) using a new perfusion agent (flurpiridaz F 18) (n = 16) and Rb-82 (n = 14), acquired on a Siemens Biograph-64 scanner in list mode. Stress and rest images were reconstructed into 4 (Rb-82) or 10 (flurpiridaz F 18) dynamic frames (60 s each) using standard reconstruction (2D attenuation weighted ordered subsets expectation maximization). Patient motion correction was achieved by an image-based registration scheme optimizing a cost function using modified normalized cross-correlation that combined global and local features. For comparison, visual scoring of motion was performed on the scale of 0 to 2 (no motion, moderate motion, and large motion) by two experienced observers.
Results: The proposed registration technique had a 93% success rate in removing left ventricular motion, as visually assessed. The maximum detected motion extent for stress and rest were 5.2 mm and 4.9 mm for flurpiridaz F 18 perfusion and 3.0 mm and 4.3 mm for Rb-82 perfusion studies, respectively. Motion extent (maximum frame-to-frame displacement) obtained for stress and rest were (2.2 +/- 1.1, 1.4 +/- 0.7, 1.9 +/- 1.3) mm and (2.0 +/- 1.1, 1.2 +/- 0.9, 1.9 +/- 0.9) mm for flurpiridaz F 18 perfusion studies and (1.9 +/- 0.7, 0.7 +/- 0.6, 1.3 +/- 0.6) mm and (2.0 +/- 0.9, 0.6 +/- 0.4, 1.2 +/- 1.2) mm for Rb-82 perfusion studies, respectively. A visually detectable patient motion threshold was established to be >= 2.2 mm, corresponding to visual user scores of 1 and 2. After motion correction, the average increases in contrast-to-noise ratio (CNR) from all frames for larger than the motion threshold were 16.2% in stress flurpiridaz F 18 and 12.2% in rest flurpiridaz F 18 studies. The average increases in CNR were 4.6% in stress Rb-82 studies and 4.3% in rest Rb-82 studies.
Conclusions: Fully automatic motion correction of dynamic PET frames can be performed accurately, potentially allowing improved image quantification of cardiac PET data.

• 出版日期2011-11