Diminished adult neurogenesis in the marmoset brain precedes old age

作者：Leuner Benedetta; Kozorovitskiy Yevgenia; Gross Charles G^*; Gould Elizabeth

来源：Proceedings of the National Academy of Sciences, 2007, 104(43): 17169-17173.

DOI：10.1073/pnas.0708228104

• aging
• BrdU
• dentate gyrus
• hippocampus
• subventricular zone

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.

• 出版日期2007-10-23