Dietary β-glucan enhances the contents of complement component 3 and factor B in eggs of zebrafish

作者：Jiang, Chengyan; Wang, Peng; Li, Mengyang; Liu, Shousheng; Zhang, Shicui^*

来源：Developmental and Comparative Immunology, 2016, 65: 107-113.

DOI：10.1016/j.dci.2016.06.022

• Zebrafish
• Danio rerio
• Immunostimulator
• Glucan
• Maternal immunity

beta-glucan has been shown to increase non-specific immunity and resistance against infections or pathogenic bacteria in several fish species, but no information is available regarding its trans-generational effects to date. Here we clearly demonstrated that beta-glucan enhanced the contents of immune relevant molecules C3 and Bf in eggs of zebrafish, and the embryos derived from beta-1,3 glucan-treated zebrafish were more resistant to bacterial challenge than control embryos. Moreover, the transferred C3 and Bf were directly associated with the antimicrobial defense of early embryos. In addition, feeding female zebrafish with beta-glucan had little detrimental effects on the number of spawned eggs and their embryonic development. Collectively, these data show for the first time that beta-glucan can be safely used to promote the non-specific immunity in offspring of fishes.

• 出版日期2016-12
• 单位中国海洋大学