Aptasensors for biosecurity applications

作者：Fischer Nicholas; Tarasow Theodore M; Tok Jeffrey B H^*

来源：Current Opinion in Chemical Biology, 2007, 11(3): 316-328.

DOI：10.1016/j.cbpa.2007.05.017

Nucleic acid (aptasensors) have found steadily increased utility and application over the past decade. In particular, aptamers have been touted as a valuable complement to and, in some cases, replacement for antibodies owing to their structural and functional robustness as well as their ease in generation and synthesis. They are thus attractive for biosecurity applications (e.g. pathogen detection) and are especially well suited because their in vitro generation process does not require infection of any host systems. Herein we provide a brief overview of the aptamers generated against pathogens and toxins over the past few years. In addition, a few recently described detection platforms using aptamers and potentially suitable applications for biosecurity will be discussed.

• 出版日期2007-6