An efficient method for the preparation of tert-butyl esters from benzyl cyanide and tert-butyl hydroperoxide under the metal free condition

作者：Chen, Xiuling^*; Li, Yan; Wu, Minghu; Guo, Haibing; Jiang, Longqiang; Wang, Jian; Sun, Shaofa^*

来源：RSC Advances, 2016, 6(104): 102023-102027.

DOI：10.1039/c6ra20966a

• C-C BOND
• PALLADIUM-CATALYZED CYANATION
• CARBON-CARBON BONDS
• H BOND
• ALPHA-KETOAMIDES
• ARYL HALIDES
• MILD CONDITIONS
• RECENT PROGRESS
• CLEAVAGE
• ACETONITRILE

A novel protocol to synthesize tert-butyl esters from benzyl cyanides and tert-butyl hydroperoxide has been successfully achieved. In the presence of tert-butyl hydroperoxide, Csp(3)-H bond oxidation, C-CN bond cleavage and C-O bond formation proceeded smoothly in one pot under the metal-free condition.

• 出版日期2016
• 单位湖北科技学院