Diphenylhydantoin-Induced Severe yet Reversible Anemia during Pregnancy

作者：Sugaya Akinori; Nakamagoe Kiyotaka^*; Okoshi Yasushi; Obata Yasuoka Mana; Tamaoka Akira

来源：Internal Medicine, 2010, 49(22): 2515-2518.

DOI：10.2169/internalmedicine.49.4026

• epileptic seizures
• anemia
• diphenylhydantoin
• pure red-cell aplasia
• haemolytic anemia

Diphenylhydantoin (DPH) therapy, often used in treating epileptic seizures, can cause anemia in some patients. A 26-year-old female suffered from convulsions due to encephalitis and was placed on DPH therapy. About two months after the initiation of DPH therapy, her hemoglobin level was 3.8 g/dL. Her anemia improved after the discontinuation of DPH, confirming that the anemia was caused by DPH. Pure red-cell aplasia (PRCA) combined with hemolytic anemia was indicated by results such as erythroid aplasia, an increased LDH level, and a decreased haptoglobin level. PRCA complicated by hemolytic anemia could be responsible for anemia associated with DPH.

• 出版日期2010