Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity

作者：Takano Shingo^*; Mashiko Ryota; Osuka Satoru; Ishikawa Eiichi; Ohneda Osamu; Matsumura Akira

来源：Brain Tumor Pathology, 2010, 27(2): 89-94.

DOI：10.1007/s10014-010-0271-y

• Malignant glioma
• Bevacizumab
• Irinotecan
• Metalloproteinase
• Zymogram

Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treatment for malignant glioma through upregulation of metalloproteinase activity in the urine, as well as infiltrative tumors on MRI. In addition, MMP9 has been proved as a molecule that facilitates its infiltrative behavior in vivo in the brain animal model.

• 出版日期2010-10